Company Partnering Contact Sitemap Home

DirectHalerTM Nasal

DirectHaler™ Nasal is an innovative, new and world-wide patented dry powder nasal delivery device. The device applies advanced principles to activate the anatomy of the patient for increased nasal delivery efficiency and patient acceptability.

Anatomy is key in nasal delivery
Efficiency and patient acceptability of nasal delivery highly depends on attention to anatomical issues:

  • Problem: The effective clearing mechanism of the nasal cavity reduces the time for drug absorption.
  • Problem: Open passage between nasal and oral cavity during nasal dose delivery can disturb the nasal delivery by:
    - Risk of Inhalation of the dose to the lung or
    - Risk of Immediate swallowing (with risk of taste disturbance).

DirectHaler™ Nasal is designed to overcome these problems and risks in nasal delivery.

DirectHaler™ Nasal is both delivery innovation and device  innovation
DirectHaler™ Nasal is intuitively easy-to-use, which will minimize the instruction task – and ease any checking of the patient delivery technique.
The pre-metered and pre-filled powder dose in the DirectHaler™ Nasal, is always visible and ready for delivery because the device is primeless and transparent.

The transparency allows the patient to have visual contact with the dose – ensuring confirmed "dose ready" before delivery and "dose taken" after delivery. The compact device dimensions ensure portability and discretion in using the device.

DirectHaler™ Nasal introduces the unique and patented Nasal Seal delivery principle
The combination of DirectHaler™ Nasal and the human anatomy, prevents the nasally delivered compound from being deposited in lungs and trachea, we call this principle Nasal Seal: When the patient applies the blow into the mouthpiece of DirectHaler™ Nasal, then the airway connection between the nasal cavity and trachea closes.

The delivery blow of the nasal dose is completed when the finger-activated flow-valve is released. After completion of the dose delivery blow, the anatomy returns to its “open” state again.

Known problems with marketed nasal devices will be solved with DirectHalerTM Nasal
The DirectHaler™ Nasal is designed with attention to the key issues in dry powder nasal delivery, and for achieving improved delivery and patient compliance.

DirectHaler™ Nasal provides a novel opportunity for overcoming the recognised problems of currently marketed nasal delivery device concepts:

Problems Solved by DirectHalerTM Nasal
Risk of liquid dose dripping out from nostril. Dry powder nasal dose sticks to nasal epitelium.
Risk of liquid dose swallowed immediately after delivery - giving limited absorption time and unpleasant taste. NasalSeal principle closes nasal cavity. Preventing immediate dose swallowing and taste disturbance.
Risk of "snorting-in" powder dose being inhaled to lungs. NasalSeal principle closes passage between oral and nasal cavity. Preventing inhalation to lungs.
Bulky insufflator devices limiting the portability and discretion in use. Compact device size ensures high portability and discretion in use.
Complicated and time-consuming insufflation device procedures making acute-use difficult. Easy-to-use and easy-to-instruct. Suitable for acute-use
Unpleasant "cold-blow" of medication from pMDI. Patient generated air-blow ensures convenient blow temperature perception in nasal cavity.
Unhygienic multi-use device concepts, necessitating preservatives in formulation and frequent device cleaning. DirectHalerTM Nasal is for single-use and is disposable. Does not require preservatives and cleaning.